Nuclear lamins and laminopathies
نویسندگان
چکیده
منابع مشابه
Nuclear lamins: laminopathies and their role in premature ageing.
It has been demonstrated that nuclear lamins are important proteins in maintaining cellular as well as nuclear integrity, and in maintaining chromatin organization in the nucleus. Moreover, there is growing evidence that lamins play a prominent role in transcriptional control. The family of laminopathies is a fast-growing group of diseases caused by abnormalities in the structure or processing ...
متن کاملNuclear Lamins a and B1
At the end of mitosis, the nuclear lamins assemble to form the nuclear lamina during nuclear envelope formation in daughter cells. We have fused A- and B-type nuclear lamins to the green fluorescent protein to study this process in living cells. The results reveal that the A- and B-type lamins exhibit different pathways of assembly. In the early stages of mitosis, both lamins are distributed th...
متن کاملNuclear lamins in cancer.
Dysmorphic nuclei are commonly seen in cancers and provide strong motivation for studying the main structural proteins of nuclei, the lamins, in cancer. Past studies have also demonstrated the significance of microenvironment mechanics to cancer progression, which is extremely interesting because the lamina was recently shown to be mechanosensitive. Here, we review current knowledge relating ca...
متن کاملImplications and Assessment of the Elastic Behavior of Lamins in Laminopathies
Lamins are mechanosensitive and elastic components of the nuclear lamina that respond to external mechanical cues by altering gene regulation in a feedback mechanism. Numerous mutations in A-type lamins cause a plethora of diverse diseases collectively termed as laminopathies, the majority of which are characterized by irregularly shaped, fragile, and plastic nuclei. These nuclei are challenged...
متن کاملNuclear lamins of erythrocyte and liver.
Lamins A, B, and C are the most abundant proteins in a residual nuclear envelope fraction derived from the nuclear lamina. They have been separated and identified in several tissues by two-dimensional electrophoresis based on their isoelectric points and molecular weights. Molecular weights and ionic properties have been conserved in the evolution of chickens and rats. Lamins purified from chic...
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ژورنال
عنوان ژورنال: The Journal of Pathology
سال: 2011
ISSN: 0022-3417
DOI: 10.1002/path.2999